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Dementia theme icons highlighting biological mechanisms and therapeutics icon

Biological mechanisms and therapeutics

‌Leads: Professor Nigel Hooper, Professor Stuart Pickering-Brown and Professor Ian Stratford

There is an urgent need for new therapeutics in dementia.

Investigation of the underlying biological mechanisms is critical for the identification of new therapeutic targets, and the development of novel therapies.

Through the use of molecular and cellular modelling, molecular dissection techniques such as proteomics, lipidomics and metabolomics, in combination with information derived from genetic studies, we are mapping the molecular pathways in neurodegeneration.

Drug discovery or repositioning is combined with high-throughput phenotypic screens to exploit these therapeutic targets.

Our current key strengths are:

  • Proteostasis dysfunction
  • Neuroinflammation 
  • Neurovascular dysfunction
  • Endotypes, targets and biomarkers